Laura-Lee Clancy Kelley, Ph.D.

Science Technical Specialist

Scenes from the CCSU campus at spring time:

Iwo Jima Memorial

Inner Courtyard Davidson Hall

Fish pond

Ph.D. 2003, Pharmacy, University of Georgia

M.S. 1986, Crystallography, University of Pittsburgh
B.S. 1972, Medical Technology, Michigan State University 

PDB Protein Structure Depositions

1SGW, “Putative ABC Transporter (ATP-Binding Protein) from Pyrococcus furiosus Pfu-867808-001,” 24-Feb-2004.

1SHE, 2PK8, “Conserved Hypothetical Protein from Pyrococcus furiosus Pfu-871755-001,” 25-Feb-2004.

1TWL, “Inorganic Pyrophosphatase from Pyrococcus furiosus Pfu-264096-001,” 01-Jul-2004.

Copernicus from another viewpoint

Department of Chemistry

418 Nicolas Copernicus Hall

Central Connecticut State University

1650 Stanley Street

New Britain, CT 06050

Phone:    860-832-2685

Fax:        860-832-2704

1XI3, “Thiamine Phosphate Pyrophosphorylase from Pyrococcus furiosus Pfu-1255191-001,” 21-Sep-2004.

1XX7, “Conserved Hypothetical Protein from Pyrococcus furiosus Pfu-403030-001,” 04-Nov-2004.

1YBZ, “Conserved Hypothetical Protein from Pyrococcus furiosus Pfu-1581948-001,” 21-Dec-2004.

View of Student Union, Library & Memorial Hall

PUBLICATIONS

1.   Laura-Lee Clancy Kelley, Bret D. Dillard, Wolfram Tempel, Lirong Chen, Neil Shaw, Doowon Lee, M. Gary Newton, Frank J. Sugar, Francis E. Jenney Jr, Han Seung Lee, Claudia Shah, Farris L. Poole III, Michael W. W. Adams, Jane S. Richardson, David C. Richardson, Bi-Cheng Wang, Zhi-Jie Liua, and John P. Rose, “Crystal structure of a conserved hypothetical protein PF0899 from Pyrococcus furiosus at 1.85 Å resolution,” (2007) Acta Crystallographica, F63, in press.

2.   Ashwini Nadkarni, Laura-Lee Clancy Kelley, Cory Momany, “Optimization of a Mouse Recombinant Antibody Fragment for Efficient Production from Escherichia coli,” Protein Expr Purif. 2007 Mar;52(1):219-29. Epub 2006 Oct 26.

3.   Laura-Lee Clancy Kelley, Zhi-Jie Liu, Wolfram Tempel, Lirong Chen, Jeff Habel, Doowon Lee, Bret D. Dillard, John P. Rose, Francis. E. Jenney Jr., Frank J. Sugar, Jane S. Richardson, David C. Richardson, M. Gary Newton, Michael W. W. Adams, Bi-Cheng Wang, “Structural and Transcriptional Analyses of an ATP-Binding Protein from Pyrococcus furiosus; a Component of a Novel Membrane-Bound Multiprotein Complex Unique to this Hyperthermophylic Archaeon,” Proteins: Structure, Function and Bioinformatics, C, submitted, 2006, under extensive revision due to the withdrawal of the ABC transporter papers.

4.   Laura-Lee Clancy Kelley and Cory Momany, “Generation of a Phagemid Mouse Recombinant Antibody Fragment Library by Multi-Site Directed Mutagenesis,” (2003) BioTechniques. Oct;35(4):750-756.

5.   Kyeong Lee, Wen Zhou, Laura-Lee C. Kelley, Cory Momany and Chung K. Chu, “Synthesis of unsaturated fluoride containing - and -pyranosyl nucleosides,” (2002) Tetrahedron: Asymmetry, 13(15): 1589-1598

6.   Clare, P.M., Poorman, R.A., Kelley, Laura-Lee C., Watenpaugh, K.D., Bannow, C.A., and Leach, K.L. “The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism,” (2001) J. Biol. Chem., 276: 48292-48299.  PDB ID: 1JSV

7.   Eric T. Baldwin, Ronald W. Sarver, Garold L. Bryant, Jr., Kimberly A. Curry, Michael B. Fairbanks, Barry C. Finzel, Robert L. Garlick, Robert L. Heinrickson, Nancy C. Horton, Laura-Lee C. Kelley, Ana M. Mildner, Joseph B. Moon, John E. Mott, Veronica T. Mutchler, Che-Shen C. Tomich, Keith D. Watenpaugh and Veronica H. Wiley, "Cation binding to the integren CD11b I domain and activation model assessment," (1998) Structure, 6: 923-935. PDB ID:  1BHO, 1BHQ, 1IDN.

8.   Laura L. Clancy, B. C. Finzel,  A. W. Yem, M. R. Deibel, Jr., N. A. Strakalaitis, D. P. Brunner, R. M. Sweet and H. M. Einspahr, "Initial Crystallographic Analysis of a Recombinant Human Interleukin-1 Receptor Antagonist Protein," (1994) Acta Crystallographica, D50: 197-201. PDB ID:  2IRT.

9.   Lawrence J. DeLucas, M. M. Long, K. M. Moore, W. M. Rosenblum, T. L. Bray, C. Smith, M. Carson, S. V. L. Narayana, M. D. Harrington , D. C. Carter, A. D. Clark, Jr., R.  G. Nanni, J. Ding, A. Jacobo-Molina,  G. Kamer, S. H. Hughes, E. Arnold, H. M. Einspahr, Laura L. Clancy, G. S. J. Rao, P. F. Cook, B. G. Harris, S. H. Munson, B. C. Finzel, A. McPherson, P. C. Weber, F. Lewandowski, T. L. Nagabhushan, P. P. Trotta, P. Reichert, M. A. Navia,  K. P.Wilson, J. A.Thomson, R. N. Richards, K. D. Bowersox, C. J. Meade, E. S. Baker, S. P. Bishop, B. J. Dunbar, E.Trinh, J. Prahl, A. Sacco, Jr. and C. E. Bugg, "Recent results and new hardware developments for protein crystal growth in microgravity," (1994) J. Crystal Growth, 135: 183-195.

10. Lawrence J. DeLucas, Karen M. Moore, Terry L. Bray, William M. Rosenblum, Howard M. Einspahr, Laura L. Clancy, G. S. J. Rao, B. G. Harris, S. H. Munson, B. C. Finzel and Charles E. Bugg, "Protein crystal growth results from the United States Microgravity Laboratory - 1 mission," (1993) J. Phys. D:  Appl. Phys., 26: B100-B103.

11. DeLucas, Lawrence J. ..., Einspahr, H. M., Clancy, L. L., Finzel, B. C.,..., and Bugg, C. E., "Protein Crystal Growth Aboard U. S. Space Shuttle Flights STS-31 and STS-32," (1992) Adv. Space Res., 12 (1): 393-400.

12. Laura L. Clancy, B. C. Finzel, S. W. Muchmore, D. R. Holland, K. D. Watenpaugh, H. M. Krishnamurthy, G. S. J. Rao, P. F. Cook, B. G. Harris, and H. M. Einspahr, "Crystallization of the NAD-dependent Malic Enzyme from the Parasitic Nematode Ascaris suum," (1992) J. Mol. Biol.  226, 565-569.

13. Qi Gao, Laura L. Clancy, Hans-Peter Weber, Bryan M. Craven and Robert K. McMullen, "Structure of the Adipate Complex [Na₂ (C₆H₉O₄) (C₆H₁₀O₄)] ₂ ^.H₂O from Neutron Diffraction at 220 and 295 K," (1991) Acta Crystallographica B47, 368-375.

14. Lawrence J. DeLucas, C. D. Smith, H. W. Smith, S. Vijay-Kumar, S. E. Senadhi, S. E. Ealick, D. C. Carter, R. S. Snyder, P. C. Weber, F. R. Salemme, D. H. Ohlendorf, H. M. Einspahr, Laura L. Clancy, M. A. Navia, B. M. McKeever, T. L. Nagabhushan, G. Nelson, A. McPherson, S. Koszelak,  G. Taylor,  D. Stammers, K. Powell, G. Darby, and C. E. Bugg, "Protein Crystal Growth Results for Shuttle Flights STS-26 and STS-29," (1991) J. Crystal Growth, 110, 302-311.

15. Laura L. Clancy, T. J. Ridel, S. W.  Muchmore, D. R. Holland, K. D. Watenpaugh, B. C. Finzel and H. M. Einspahr, "Crystal Forms of a Lysine-49 Phospholipase A₂ from the Eastern Cottonmouth Snake," (1990) J. Crystal Growth, 104, 868-870.

16. D. R. Holland, Laura L. Clancy, S. W. Muchmore, T. R. Rydel, H. M. Einspahr, B. C. Finzel, R. L. Heinrikson and K. D. Watenpaugh, "The Crystal Structure of Lysine-49 Phospholipase A₂ from the Venom of Agkistrodon piscivorus piscivorus at 2.0 A Resolution," (1990) J. Biol. Chem., 265, 17649-17656.

17. Lawrence J. DeLucas, C. D. Smith, H.W. Smith, S. Vijay-Kumar, S. E. Senadhi, S. E. Ealick, D. C. Carter, R. S. Snyder, P. C. Weber, F. R. Salemme, D. H. Ohlendorf, H. M. Einspahr, Laura L. Clancy, M. A. Navia, B. M. McKeever, T. L. Nagabhushan, G. Nelson,  A. McPherson, S. Koszelak,  G.Taylor,  D. Stammers, K. Powell, G. Darby, and C. E. Bugg, "Protein Crystal Growth in Microgravity," (1989) Science, 246, 651-654.

18. Barry C. Finzel, Laura L. Clancy, Debra R. Holland, Steven W. Muchmore, Keith D. Watenpaugh, and Howard M. Einspahr,  "The Crystal Structure of Recombinant Human Interleukin-1b at 2.0 A Resolution," (1989) J. Molec. Biol., 209(4), 779-792. PDB ID: 1I1B.

19. Howard M. Einspahr, Laura L. Clancy, S.W. Muchmore, K.D. Watenpaugh, P.K.W. Harris, D.B. Carter,  K.A. Curry,C.-S.C. Tomich, A.W. Yem, M.R. Diebel, Jr.,D.E. Tracey, J.W. Paslay, N.D. Staite, J.B. Carte, N.Y. Theriault, I.M. Reardon, H.A. Zurcher-Neely, and R.L. Heinrickson,"Crystallization of Recombinant Human Interleukin-1b," (1988) J.Crystal Growth, 90 180-187.

20. D.B. Carter, K. A. Curry, C-S.C. Tomich, A.W. Yem, M. Deibel, D.E. Tracey, J.W. Paslay, J.B. Carter, N.Y. Theriault,  P.K.W. Harris,  I.M. Reardon, H.A. Zurcher-Neely, R. L. Heinrikson, Laura L. Clancy, S.W.  Muchmore, K.D. Watenpaugh, and H.M. Einspahr, "Crystallization of Purified Recombinant Human Interleukin-1b," (1988) Proteins: Structure, Function and Genetics, 3, 121-129.

21. William Furey, Arthur H. Robbins, Laura L. Clancy, Dennis R. Winge, Bi C. Wang,  and C. David  Stout, "Crystal Structure of Cd, Zn Metallothionein," (1987) Experientia Suppl. 52:139-48.

22. William Furey, Arthur H. Robbins, Laura L. Clancy, Dennis R. Winge, Bi C. Wang,  and C. David  Stout, "Crystal Structure of Cd, Zn Metallothionein," (1986) Science, 231, 704-710.  PDB ID:  4MT2.

BOOK  CHAPTER

Howard M. Einspahr, Laura L. Clancy, D. R. Holland, S.W. Muchmore, K. D. Watenpaugh, and  B. C. Finzel, "The Crystal Structure of Human Recombinant Interleukin-1a," In Current Research in Protein Chemistry, (1990) J. J. Villafranca, ed., Academic Press: San Diego, pp.351-358.

REFERENCES

Date this page was updated:  05/31/2007